Distant tumors and orbital involvement as initial manifestation

Authors

  • Martina Faretta Hospital Interzonal General de Agudos Dr. Rodolfo Rossi, La Plata, Argentina
  • Joaquín Rodríguez Hospital Interzonal General de Agudos Dr. Rodolfo Rossi, La Plata, Argentina
  • Laura Cardozo Hospital Interzonal General de Agudos Dr. Rodolfo Rossi, La Plata, Argentina
  • Camila Rocco Hospital Interzonal General de Agudos Dr. Rodolfo Rossi, La Plata, Argentina
  • Andrea Valeiras Hospital Interzonal General de Agudos Dr. Rodolfo Rossi, La Plata, Argentina

DOI:

https://doi.org/10.70313/2718.7446.v16.n03.242

Keywords:

orbit, orbital tumors, metástasis

Abstract

Objective: To review the short-term frequency of occurrence and characteristics of cases with orbital metastases from distant localized primary tumors.

Methods: Retrospective study of a case series was performed, including patients who had orbital metastases from distant localized primary tumors, seen between January and February 2023 in an ophthalmology service. Characteristics such as gender, age, location of the primary tumor, form of presentation, diagnostic methods, treatment, evolution and survival since diagnosis were evaluated.

Results: During the study period, 462 patients were seen in the ophthalmology department and three cases (0.6%) met the inclusion criteria. The mean age at diagnosis was 45.6 years (range 29-6). In all 3 cases the metastasis was unilateral. The locations of the primary tumor were breast, lung and testis. Only 1 patient had neoplastic disease diagnosed at the time of ophthalmologic consultation. The most frequent signs and symptoms were pain, bulbar hyperemia, proptosis, ptosis, diplopia and decreased visual acuity. Median survival was 3.8 months from the time of diagnosis. Patients with testicular and breast cancer died within a short time from the time of consultation.

Conclusions: In two months, 3 cases of orbital metastases of testicular, lung and breast tumors were found, representing 0.6% of the cases seen in our service. In two cases (66%), the orbital manifestations preceded the detection of the primary tumor.

Downloads

Download data is not yet available.

References

Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part 1. Ophthalmology 2004; 111: 997-1008.

Rootman J. Diseases of the orbit. 2nd ed. Baltimore: Lippincot Williams & Wilkins; 2003, p. 330-343.

Char DH, American Cancer Society. Tumors of the eye and ocular adnexa. Hamilton, Canada: B. C. Decker, 2001, p. 413-420.

Char DH, Miller T, Kroll S. Orbital metastases: diagnosis and course. Br J Ophthalmol 1997; 81: 386-390.

Goldberg RA, Rootman J, Cline RA. Tumors metastatic to the orbit: a changing picture. Surv Ophthalmol 1990; 35: 1-24.

Font RL, Ferry AP. Carcinoma metastatic to the eye and orbit III: a clinicopathologic study of 28 cases metastatic to the orbit. Cancer 1976; 38: 1326-1335.

Dieing A, Schulz CO, Schmid P et al. Orbital metastases in breast cancer: report of two cases and review of the literature. J Cancer Res Clin Oncol 2004; 130: 745-748.

Shields JA, Shields CL, Brotman HK et al. Cancer metastatic to the orbit: the 2000 Robert M. Curtis Lecture. Ophthalmic Plast Reconstr Surg 2001; 17: 346-354.

Albert DM, Rubenstein RA, Scheie HG. Tumor metastasis to the eye. I. Incidence in 213 adult patients with generalized malignancy. Am J Ophthalmol 1967; 63: 723-726.

Ferry AP, Font RL. Carcinoma metastatic to the eye and orbit. I. A clinicopathologic study of 227 cases. Arch Ophthalmol 1974; 92: 276-286.

Merrill CF, Kaufman DI, Dimitrov NV. Breast cancer metastatic to the eye is a common entity. Cancer 1991; 68: 623-627.

Kennerdell JS, Slamovits TL, Dekker A, Johnson BL. Orbital fine-needle aspiration biopsy. Am J Ophthalmol 1985; 99: 547-551.

Zeppa P, Tranfa F, Errico ME et al. Fine-needle aspiration (FNA) biopsy of orbital masses: a critical review of 51 cases. Cytopathology 1997; 8: 366-372.

Bullock JD, Yanes B. Ophthalmic manifestations of metastatic breast cancer. Ophthalmology 1980; 87: 961-973.

Wladis EJ, Lee KW, Nazeer T. Metastases of systemic malignancies to the orbit: a major review. Orbit 2021; 40: 93-97.

Published

2023-09-26

Issue

Section

Original Articles

How to Cite

[1]
2023. Distant tumors and orbital involvement as initial manifestation. Oftalmología Clínica y Experimental. 16, 3 (Sep. 2023), e251-e259. DOI:https://doi.org/10.70313/2718.7446.v16.n03.242.

Similar Articles

1-10 of 50

You may also start an advanced similarity search for this article.

Most read articles by the same author(s)

1 2 > >>